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Nicorette NRT & combination therapy for smokers

Data from a Cochrane review showed that compared with the use of a single NRT product, combination NRT can increase long-term quit smoking rates by 27%.2

NRT Products

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NICORETTE® 2mg Gum 105s - front shot

Nicorette Original 2mg Gum 105s

NICORETTE® Quickmist Mouthspray

Nicorette Quickmist Mouthspray (nicotine)

Nicorette InvisiPatch

Nicorette InvisiPatch™ (nicotine)

NICORETTE® Nasal Spray 10ml

Nicorette Nasal Spray 10ml

See all NRT products

Combination Therapy Training

Nothing is more effective than combination NRT to help smokers quit for good vs single NRT or other smoking cessation medications available OTC.

The training includes an overview of Nicorette® Combination Therapy, its effectiveness, dosing guidelines, and strategies to address common barriers to quitting smoking.

View Training Deck - Prescribers
View Training Deck - Non-prescribers

The recommended dosage guidelines for Nicorette® Combination Therapy 4-10

Consider offering a combination of nicotine patch and flexible form of NRT (such as mouthspray, gum, lozenge, inhalator or nasal spray) to smokers who show a high level of dependence on nicotine, or who have found single forms of NRT inadequate in the past.11

Nicorette Invisi Patch

+  Nicorette Quick  Mist Mouthspray

OR  Nicorette Gum

OR  Nicorette Lozenge

OR  Nicorette Microtab

OR  Nicorette  Nasal Spray

OR  Nicorette  Inhalator

Slow release NRT  All-day relief from background withdrawal

Fast release NRT

Relieves sudden cravings whenever they strike

Fast release NRT

Relieves sudden cravings whenever they strike

Fast release NRT

Relieves sudden cravings whenever they strike

Fast release NRT

Relieves sudden cravings whenever they strike

Fast release NRT

Relieves sudden cravings whenever they strike

Fast release NRT

Relieves sudden cravings whenever they strike

16 hour patch specifically designed to be removed at night, so as not to add to the sleep disturbance caused due to nicotine withdrawal

Clinically proven to start relieving cravings in 30s.12

Relieves tough cravings. For those who like to chew gums to control cravings. Icy white flavour also improves teeth whiteness.13

Starts to fight craving in just 2 minutes. Dual-layer flavour technology designed to aid compliance.7

Flexible and discreet, no chewing is required.10

Rapid uptake of nicotine for fast relief of cravings.9

Mimics the hand-tomouth ritual of smoking.8

Strengths available: 10mg, 15mg, 25mg

Strengths available: 1mg/spray

Strengths available: 2mg, 4mg

Strengths available: 2mg, 4mg

Strengths available: 2mg

Strengths available: 0.5mg/ spray

Strengths available: 15mg

Maximum dose: 1 patch daily

Maximum dose: 64 sprays in any 24 hour period

Maximum dose: 15 pieces per day

Maximum dose: 15 pieces per day

Maximum dose: 40 tablets per day

Maximum dose: 64 sprays in any 24 hour period

Maximum dose: 6 cartridges per day

   

Freshmint Cool berry

Original Icy white Fruitfusion Freshmint

Icy mint Fruit

Nicorette NRT & Combination Therapy Resources

See all smoking cessation resources
Smoking and vaping cessation

Helping patients quit smoking: Nicotine Replacement Therapy (NRT) & pharmacotherapy

Read more
Chart on NRT success rate
Smoking and vaping cessation

Nicotine Replacement Therapy (NRT)

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Smoking and vaping cessation

Why prescribe combination nicotine replacement therapy?

Read more

Combination NRT

Read more
See all smoking cessation resources

References

  1. L indson N, et al. Cochrane Database Syst Rev. 2019 Apr 18;4(4):CD013308.

  2. Theodoulou, A., Chepkin, S.C., Ye, W., Fanshawe, T.R., Bullen, C., Hartmann-Boyce, J., Livingstone-Banks, J., Hajizadeh, A. and Lindson, N., 2023. Differentdoses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.Cochrane Database of Systematic Reviews, (6).

  3. NICE guideline [NG209] Tobacco: preventing uptake, promoting quitting and treating dependence. 30 November 2021

  4. Nicorette® Invisi 25 mg Patch. Summary of Product Characteristics Oct 2024.

  5. Nicorette® QuickMist. Summary of Product Characteristics. Dec 2022.

  6. Nicorette® 4mg Gum Summary of Product Characteristics. Sep 2021.

  7. Nicorette® Cools 4mg Lozenge Summary of Product Characteristics. May 2024.

  8. Nicorette® 15mg inhalator. Summary of Product Characteristics. Oct 2024.

  9. Nicorette® Nasal Spray Summary of Product Characteristics. Mar 2023.

  10. Nicorette® 2mg Microtab Summary of Product Characteristics. Sep 2021.

  11. National Center for Smoking Cessation and Training. Combination nicotine replacement therapy. https://www.ncsct.co.uk/library/view/p df/combination-NRT-2024-25-v1.pdf accessed Sept 25

  12. Tønnesen P et al. Eur Respir J 1999;13(2):238-246.

  13. McCaffrey V et al. P Consilium 2019;21(11)28-33.

    https://journals.eco-vector.com/2075-1753/article/view/96778

UK-NIC-2025-241219 | October 2025