English ivy leaf (Hedera helix)

Properties and mechanism of action

Ivy leaf contains saponins, flavonoids, and other phenolic compounds, and exhibits respiratory-supporting properties.1* While the exact mechanism of action is not known, the saponins in ivy leaf are believed to help clear mucus from the chest and to induce relaxation of the airway.²* It has also been observed that ivy leaf both widens the bronchi in the lungs and stimulates bronchial glands to secrete fluid.³*

Scientific support

The benefits of ivy leaf extract in improving cough associated with hoarseness, dry throat, and irritants* have been demonstrated in multiple clinical trials involving both adults and children.^1,4

^{*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.} 

^{Ingredient details are provided as general information and are not intended to be associated with any specific Zarbee’s® products.} 

^REFERENCES: 

 ^{1. Lang C, Röttger-Lüer P, Staiger C. A valuable option for the treatment of respiratory diseases: review on the clinical evidence of the ivy leaves dry extract EA 575®. Planta Med. 2015;81(12-13):968-974. 2. Wolf A, Gosens R, Meurs H, Häberlein H. Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle. Phytomedicine. 2011;18(2-3):214-218. 3. Ivy leaf. European medicines agency science medicines health. Published November 21, 2017. Accessed July 7, 2021. https://www.ema.europa.eu/en/documents/herbal-summary/ivy-leaf-summary-public_en-0.pdf}

^{4. Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine. 2009;16(1):17-24.}