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Tolerability

The data confirm that ZYRTEC® is generally well tolerated1

Discontinuation Due to Somnolence in Adult Clinical Trials1

  • Discontinuation due to adverse events in clinical trials was not significantly different between ZYRTEC® and placebo (2.9% vs 2.4%, respectively)1 

  • 14% reported somnolence with ZYRTEC® vs 6% with placebo 

 

Somnolence rates 1 

Zyrtec Tolerability Somnolence rates 1

  • Of the patients reporting somnolence, the majority did so in the first week, with the rates decreasing at week 21*†

Studies show ZYRTEC® is also generally well tolerated by children.1

See pediatric data

*Retrospective analyses of data from 8 randomized, placebo-controlled allergic rhinitis studies SAR and PAR, at least 2-week long. 

†Distribution of percent (%) of safety-evaluated patients who reported somnolence after receiving a single daily dose of cetirizine 10 mg, for at least 2 weeks. Somnolence rates are shown for weeks 1 and 2. Horizontal line inside the chart box is representative of the median. 

 

Reference:  

1. Data on file, Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division.