Clinical studies – Overholser

Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis^{41, 42} 

 - Overholser CD, Meiller TF, DePaola LG, Minah GE, Niehaus C. J Clin Periodontol. 1990;17:575-579 

Objective 

Determine the efficacy of 2 mouthrinses — LISTERINE® Antiseptic and Peridex® — used as supplements to regular oral hygiene measures in reducing supragingival dental plaque and gingivitis (N=124). 

Methodology 

Double-blind, controlled, parallel design clinical study of healthy male and female subjects (aged ≥21 years) with preexisting plaque and gingivitis, but without evidence of periodontitis. 

Results 

At 6 months, gingivitis development was inhibited by 35.9% in the LISTERINE® Antiseptic group and by 30.5% in the Peridex™ group, when compared to the hydroalcohol control (P<0.001). 

 At 6 months, gingivitis development—in posterior regions—was inhibited by 33.2% and 34.4% in the LISTERINE® Antiseptic group and by 26.6% and 33.8% in the Peridex™ group, when compared to the hydroalcohol control (P<0.001).⁴²

Conclusion 

 LISTERINE® Antiseptic produces gingivitis reductions comparable to Peridex™ at 6 months (including gingivitis in posterior regions). 

^{*During the study, subjects followed their usual oral hygiene and dietary habits.}