Biofilm penetration vs. CPC

LISTERINE® Antiseptic penetrates plaque biofilm deeper than cetylpyridinium chloride (CPC)*

Rinses containing cetylpyridinium chloride only go so far, and in lab studies they have been proven to kill less bacteria.⁴²

Essential oils kill bacteria associated with plaque and gingivitis by disrupting the bacterial cell wall resulting in cell death

Penetrate and destroy bacterial cell membranes⁴⁵

Extract endotoxins from plaque bacteria that cause inflammation⁴⁵

Do not promote resistance despite daily use⁴⁵

Recommend a rinse with deeper plaque biofilm penetration:  1.8x more plaque biofilm penetration (confocal microscopy of living biofilm cells [green] and dead biofilm cells [red] at deepest layer).⁴²

^{Killing 1.8x More Bacteria than CPC1}

48 hour saliva grown plaque biofilm, treated 1x immediately before imaging (green is live, red is dead bacteria – 63x magnification)

See in 3D animation how deeply LISTERINE^® Antiseptic penetrates plaque biofilm:

^{*Lab study: Mixed species biofilm growth 48 hours prior to 30-second treatment with mouthrinse or sterile water.}